The Interaction Between Antipyretic, Analgesic, And Anti-inflammatory Drugs

(1) The combination of aspirin with coumarin anticoagulants, sulfonylurea hypoglycemic drugs, phenobarbital, phenytoin sodium, and glucocorticoids can increase the effects of these drugs due to the exchange of plasma protein binding, such as prolonging bleeding time, hypoglycemic reactions, and inducing ulcers
(2) Aspirin inhibits the secretion of methotrexate from the renal tubules and increases its toxicity. When used in combination with furosemide, it competes with the renal tubular secretion system, leading to reduced salicylic acid excretion and cumulative toxicity
(3) Aminophylline or other alkaline drugs such as sodium bicarbonate can reduce the efficacy of aspirin, while acidic drugs can increase the blood concentration of salicylic acid
(4) When aspirin is used in combination with nonsteroidal anti-inflammatory drugs such as ibuprofen, it can significantly reduce the blood drug levels of the latter and increase gastrointestinal adverse reactions.